This CRA targets initiatives that are well positioned to bring together environmental, social and economic scientists with data scientists, computational scientists, and e-infrastructure and cyber-infrastructure developers and providers for a shared goal: to solve methodological, technological and/or procedural challenges facing interdisciplinary and transdisciplinary environmental change research that involves working with large, diverse and transnational, multi-source data. The SEI CRA will closely link research thinking and technological innovation toward accelerating the full path of discovery-driven data use and open science. This will enable a broader scientific community to benefit from the identified new and potentially disruptive demonstrators or pilots toward solutions.